Also found this over on BGG (I'm sure it's somewhere here too):

This is the conclusion I came to as well. Also I realized that the final step of the elimination section states that the game ends. Therefore, like you said, the cards you control would already have been discarded.

So, I tried to find some answers before posting but couldn't. On a recent playthrough I watched, the weakness "Hospital Debts" was in play and the player resigned. They stated that the weakness is discarded according to the resignation/elimination rules and the 2xp penalty does not apply. Is this correct? Seems like a thematic disconnect to me if it is. I've tried the rules reference comparing card ownership/control, elimination/resignation timing etc. and just don't see a clear answer. So.... 1. The weakness states "at game end". If the player is "defeated/resigned" and discards ALL cards as stated in "Elimination" it seems as if the weakness effect doesn't trigger. Multiplayer vs solo? 2. Is there somewhere the timing of "game end" is listed? Thanks!