I've owned FFG version of this game for about a year and get to bust it out at least once a month with different groups. The majority of the time we play with the dice variant. It's quick, as brutal as the cards, and doesn't bog down the game. Those that have played with the cards and the dice mostly prefer the dice. (Note: I haven't played this version with anyone who's played the original besides myself.)
The ones that prefer the cards are the serious strategy gamers, those who take forever thinking about their next moves in Game of Thrones, Risk, Twilight Imperium, etc. They are also the gamers that are good at Chess or Go. They say they like the cards cause it gives them the chance to bluff or strategize against other people. While they do like DungeonQuest, I can tell that they dont' like it as much as others due to the high luck involvement.
Generally if we use the cards, games could take up to an hour and a half to two hours while the dice variant usually cuts that time in half. This is ideal for me because people usually want "another go" at it and we'll have enough time to test our luck again. I also prefer to play it atleast twice in a row given the set up time.
Also to note; no sneaking a peak at the cards when not playing. Part of the fun of the game for people is in not knowing what could happen.
As far as house rules go, we let people pick their characters, new players pick their characters first, followed by youngest. I usually pick my character last as a good sport or randomly draw one. I have a top score board written on the back of the box cover along with the loser score board (those who made it out but didn't touch the dragon chamber first). They record the name of the player, score, and their character. I also have a tally of deaths and those who've made it out (the "losers" are included in the tally for those who've made it out). This has changed gameplay in alot of ways, but it also has helped the game become more accepted by my game groups. They see there has been roughly 60 deaths vs the 12 who've made it out. They take my advice and not take the game too seriously because they'll die, die, and die some more. It also gives them the goal of getting onto the box, or unfortunatly staying around too long in the hopes of getting the high score. (Them wanting the high score has led to the majority of the last 20 or so deaths)
It also should be noted that we have played with 5 and 6 people plenty of times (two people starting at the same entrance). We've modded the rules to accomendate this in several ways. One is that two hereos starting at the same start location must move in a different direction and we let two heroes occupy the same tile if needed/there is no other option besides going into hostile squares or dead ends. We also take dead heroes treasure and put it into the discard and shuffle the discard pile into the treasure deck when it runs out. So there's still incentive for the late comers to make to the treasure horde. We also encourage people to move quickly to keep the momentum up.
This game is perfect if you just want a good drinking game. Or a casual luck game to wind down the night after an intense strategy game like Twilight Imperium or Game of Thrones. It really helps bring the group together since the players are not really competing against each other, just against the board. My groups have loved it for what it is, a brutal carnage luck game of torture and dashed dreams. Everybody remembers when they first are actually able to make it out alive or when they make the new high score. Generally everybody is happy when one person is able to make it to the dragon chamber and back out again. Good times.