We played our first game with Ghatanothoa last night and the question came up of whether the Annihilating Gaze ("Each time an investigator gains 2 or more Clue Tokens at once, he must turn a visage token faceup. If it has Ghatanothoa's face on it, he is devoured") also happens during setup when investigators get the starting clue tokens indicated on their sheets. Same goes for setting up replacement investigators when an investigator is devoured midgame.
We played without doing this, since it seemed like it would add a needless delay as investigators were drawn and devoured before they even had their first turn. But now I'm thinking that this would have the effect of making us more likely to have investigators who start with 0 or 1 clues instead of more, and limiting investigator clues is the obvious intent of this GOO power.
I know that the Dark Pharaoh herald's lose a sanity when you gain an unique item power definitely does happen during investigator setup, so maybe Ghatanothoa's power should too. Anyone here play it that way?