In looking at the preview of the upcoming expansion, it looks like Miskatonic will definitely be getting some help. This is really going to super-charge my Cthulhu/Miskatonic deck!
OK, just kidding. But seriously, it's interesting to consider why the "monster" factions have long dominated over the "human" factions. The answer used to be that the humans were short on Terror and protection against it. That just isn't the case any more as humans now have a lot of answers to terror, and yet the monsters are still dominant.
I am coming to think that the answer has more to do with cost efficiency. As I mentioned in another thread, the value of a card is radically different based on cost, with cost 1 and 2 cards being far more useful than cost 4+ cards. The reason for that has to do with domain resource distribution; players tend to have a primary domain (3+ resources) and two or three secondary domains (1 or 2 resources). Anything with cost 4+ is going to compete with that primary domain, while anything 1 or 2 cost can be paid for with one of the secondary domains. Cost 4+ cards will naturally see much less play, and will compete with each other for the one primary domain, while cost 1 and 2 cards will see far more play.
In reviewing decks submitted by some of the best players, they have something in common: they are heavily skewed toward low-cost cards, with half or more of the deck at cost 2 or less. That also helps illustrate the enormous popularity of the Khopesh, Master of the Myths, Dreamlands Fanatic, etc.: they all come in at less than the magic cost 2 barrier.
All that said, I think the main issue with Miskatonic at this point is: they don't have enough good characters at or below the 2 cost limit. They actually have some fantastic characters that can handle a wide variety of situations - and they're cost 4 or more, with only a few exceptions. I realize that the designers have been cautious about giving Misk and the Agency too many solid cheap characters because Misk or Agency flood decks used to be a thing way back in the day, but that hasn't been the case for quite some time now. Put another way: the Faculty are great but too expensive, the Students are cheap but too weak.
As such, I'm a little cautious about Seekers of Knowledge. A couple of the cards they've revealed are showing good synergy with other Miskatonic characters, which is great. But if the expansion is just more cost 4 characters that will never see play and throwaway cost 1 characters that get knocked out before doing anything of substance, it won't materially change the monster/human metagame.