i've only ever mucked around with a skill based syndicate deck once with mr. pan and parallel universe, and it was mixed with shub.
personally, and i stress personally, i didn't muck around with things like the bouncer and torch singer, which are limited beyond their abilities, and instead focused on maxing out my skill instead of lowering theirs, with things like ghoulish predator, insect swarm, brazen hoodlum, border runners and jon pechon, along with miranda keeper to seek out the syndicate support goodies.
these characters operate excellently with pan / parallel but are also quite reasonable on their own.
johnny v's dame is a given, and hard case being brought in from discard with hungry dark one is nice.
you also get altar of the blessed for +1 skill for every character you own, shub or syndicate.
plus all the support destructions and shock transforming in tommy bananas who loves being paired with a shub co-hort for some insane combat struggles, or shock transforming in hack journalist just at the right time.
tyler scindere always makes it into my syndicate decks as he's excellent value for money and costs only 3 with johnny's dame.
and you can then use the underground conspiracy which for some strange reason is a shub domain card, and the tattoed thug for some cost 2 madness. tragic celebrity comes in handy then for 3 cards drawn per draw phase.
outback poacher for more cards if you're using ghoulish predator / insect swarm / dhole ant-lion, and richard upton pickman is always sweet.
triggerman and expendable muscle are very good as you must remember that pan / parallel won't always be available and you need a fall back if he gets taken out by destructions every time he pops up, which the aforementioned shub characters are good for.
far too much for one deck, but might give you some ideas if you'd like to expand beyond the syndicate. if not then that's very cool too as a mono - syndicate can be quite the trick to play against.