I see you guys at FFG became really proficient in video-to-board game conversions. So, here's an idea:
You should make board games out of "The Sims" and "Red Dead Redemption". With former, you will attract casual auditory, people who don't know yet how cool the board games are. With latter, especially if you'd make it not only with plastic minis, but include wooden cubes as well (y'know - for those strange folk, Euro-lovers) and invite Uwe Rosenberg to take part in the design process, you will win 99% of the board game players' hearts!
This is destined to result in total pwnage.