hmmm... depends on how you play might be the right answer:
Our general game style:
Ignore every possible thing except gaining clue tokens.
Whomever has 'The Toughest' character (we choose randomly to begin with) is given all the weapons. That character is our street sweeper and within a couple of turns is usually indestructable. He gives his money and other resources to the others.
Interestingly enough I see posts about how easy it is to defeat the Ancient Ones. We generally win by preventing the Ancient One from coming but if he does come we lose, any of them have killed us easily. Only our very first game did we defeat the Ancient One.
We are on turn 4 of our current game. basic set + Kingsport. Me and my wife are playing The Urchin, The Dreamer, and the Martial Artist all drawn randomly.
We drew the Green Flame Herald so placed an additional Cultist on the first open portal. Then I just randomly added another monster which turned out ot be Soggoth? A nightmarish, double moving spider looking thing.
Well first turn spider moves, martial artist kills it after taking 3 sanity and spending a clue token. On turn 3 the Dreamer returns to Arhkam chooses a gate location with a Moon Beast on it, casts an offensive spell, and kills it. We now have 1 cultist and a creature in the Sky after 4 turns with the Terror level at zero.
We are trying out the "Storm Knight" variant (boardgamegeeks) where the Ancient One doesn't get doom tokens from open gates normally. Supposibly it is easier to start the game but leads to a more climactic ending and there is never a point where the Ancient One cannot break into the world.
By the way I am in Seattle so if there are any boardgamers who want to play a game send me an email/PM! :-)