The theme of this game is very strongly reminiscent of Bladerunner. Very scifi-noir. Now, to be clear, I have heard it said many times when discussing this game; if you come to it expecting a 'mystery' element like Clue where the players must 'solve' the crime, then you WILL be disappointed. You have to come to it as an 'experience', from the theme point of view of a down and out detective, trying his best to 'pin' the crime on the suspect he believes is most guilty. This game is more like living a few weeks in the life of Deckard, dealing with all the personal problems, issues and hassles. I hope this describes it about right. Now, this game is in NO WAY cooperative, it is purely competitive, in that you are trying to build up the guilt of your suspect, and tear down the innocence of your opponents suspects.
I think this is a very very cool game that gets easily overlooked in the catalogue of Fantasy Flights other excellent games, but it's one that should definately NOT be missed. It is worth picking up.