I figured I would be passing on this one as no one in my game group really wants a deeper fantasy type game. Surprised no one has asked already, but here goes: Can/could this be played solo, with any degree of fun?
The plus factor for me for Runebound is that it plays very well solo. Middle Earth Quest, likely not so much...
I wouldn't necessarily call this a deeper game, there is IMO a lot less to learn ruleswise than with most FFG games. Degree of fun, well, that's a pretty individual thing, right? I enjoy it, but I also enjoy Arkham Horror and Lord of the Rings solo, I know people who don't.
Only thing that you really have to think about solo is combat. But since you get a limited amount of cards AND you only have so much Strength to play with (monsters especially can usually play around 3 combat cards before being exhausted), and your goal most often from the monster POV is to survive, you can play combat cards accordingly. As the Hero, you need to decide if you're going to try and kill the monster early or take your time and do it in maybe 3 rounds or so, that decision will then influence the cards you want to use. I haven't found any issues with combat, most of the time it's clear what you want to play. Combos with previous round abilities are easy to take into consideration.