Emergency Shutdown is the best solution to Wotan. Crescentus can work, but means you actually have to break it.
Forged Activation Orders can help as well if you know it's coming.
Given that the combo is Wotan+Off the Grid, I'm wagering that Wotan is on HQ.
If I were holding an ESD, I'd consider making the sacrifices to the Allfather if that meant getting into HQ.
And lose the ESD to brain damage?
Depending on my hand size. I said I'd consider it, I didn't say it was a great plan. The one and only time I've done it was when I was playing a goofy monolith deck and I had a Net Shield that came preinstalled with it, so I had at least one prog I didn't care about.