Yesterday, after a nightmarish struggle lasting for 18 turns, I was finally able to defeat Nyarlathotep + Ghroth. The game was incredibly tense: I had three times a match ball served, and three times everything was screwed.
First time with four seals on the board and Silas considering committing suicide to score a victory by closing gates. No way, the new FAQ was in my way, with the trophy he had to spend in order to sacrifice himself, I had 4 gate trophies and I needed 5 to win.
Then with five seals on the board and an investigator in the second area of an OW ready to return and seal, and a Mythos Card bursting the seal at Independence Square
Finally Marie in the second area of the Underworld with the five clues for the sixth seal got the "you can spend one Sanity and one Stamina for each clue token you want to save. Discard the rest" and she had only one Sanity left (facepalm)
The game could have been won with Nyarly at 4 doomers, and it was won by closing with 10 doomers on the doom track, after using twice Marie's Witch Blood AND an Eltdown Shards,
Anyway, this was the end of my "Ghroth cycle". I played a complete rotation of AOs against the Nemesis Moon, and won all 24 times. Basically, some considerations:
a) the "spend one clue or roll one die" clause it's just a mental trap; there is no sense in sacrificing vital resources as clues only to avoid risking a 1/6 extra doomer to be added to the doom track
b) the only challenge is represented by the extra two doomers on the doom track, but working with a minimum of strategy allowed me to deal with this with ease, technically completely justifying the modified doom track version of the base game AOs Avi wrote some time ago