I haven't played much games, so maybe not the best advice, but here goes:
Don't be afraid to let your investigator die (unless he has good ability/cards) when you die you can get a new one, so take some risks, they might work in your favor. Save your points to buy extra elder signs. What julia said: other world cards are the ones to get, some even give you two signs.
remember that unless an adventure specifically states that you have to perform all tasks in certain order, you should just roll the dice and decide wich task you will put the dice on.
Monster tokens are worth points to. (like i said, more points saves up for elder signs) So if you have cards that let you get rid of monsters/ give you bonuses go there and take em out!
While on the subject of monster tokens: During one game, monster tokens kept popping up (normaly they go on an adventure that has empty slots for them, but once those are filled up you have to put them on an adventure of your choice) - so we ended up cramming all the monsters on the same rubbish adventure we weren't bothering to resolve anyway.
Edited by Robin Graves, 13 August 2014 - 11:03 AM.