I've been playing 2nd edition since the 80's, and only played 1 partial game of 3rd edition. I now own 2nd and 4th with everything expect 2nd Dragons.
For awhile I wanted to do Homebrew for 2nd edition, but did not wish to do so with 4th, because it is so polished.
I also did not want any expansion which mixed homebrew cards into real decks. Sleeving and high quality making processes may fix the problems in that area, but I felt I didn't want that much investment. Therefore I looked for only expansions which had new decks, which possibly meant new boards.
And I found a few:
Sewer and its expansion
Village, the one by Carsten Both
OK, Black's Tavern looks and works great. In fact There is another expansion you can use with it, Mystic Brew I think its called, lots of people used to like it, it didn't appeal to me, so I didn't add it to Black's Tavern. However, when preparing this expansion I FAILED to notice the cards allude to another UNNAMED expansion which is needed. So it is unplayable after I invested about $10 into it. I suppose those cards which work with the unnamed expansion could be removed, but I found doing so weakened the expansion so I do not use it. No one has yet to respond to what that expansion is, and this problem is not listed on Talisman Island.
The Sewer Expansion and its extra expansion are pretty good. In fact there are about 2-4 different boards you can download to use. I chose the most professional looking one. But again I oopsed in my preparation and discovered that a space in some cards is not found on the better looking board. I removed 1-3 cards, and the others I decided to game play edit. Also I did not like the stink token rules and removed them and removed all cards that dealt with stink. I also removed some other cards. It plays very well. I like it. I also made the cards from artscow and anyone can order them, so you can have a professionally made deck for this expansion, I also did this for Black's Tavern.
The Village is also another nice expansion. I don't remember any problems or mistakes. I do believe there may be 1 space that allows another expansion to be played but is not a problem. There are a couple of things that are minor I don't like, but overall it works good and is a nice expansion. Because it only had a small purchase deck, I added these cards to other Artscow decks.
Talisman Places only creates a couple of small side boards. I think they are great, but even tho I play tested 2nd edition with these expansions all listed, I don't think any of these small boards got any game play. They are a simple but fun edition to the game and the art is great!
For me, game play fun is obviously important, but also is quality of the art or design. There were a couple of other expansion I thought were promising, but the art or design was too homebrewish for my taste.
By the way I also created my own expansion for 2nd edition a Dragon expansion with a semi new deck and brand new board.
You can find it here:
I cannot speak for 3rd edition.
For 4th edition, as shared above I thought the game was so polished, that I had no interest in homebrew expansion, being even fussier than 2nd edition art and design of homebrew work. However, I was very interested in homebrew alternate endings. So I have downloaded many of them found in the wild, and I would say I like about 60% found out there. I probably have about half or a bit more of those downloaded made up and playable.
But then when I played Dragons and eventually even owned it, I was so disappointed that I didn't want to lose the expansion so I sought to fix it. I found 3 variants I thought were ok but eventually created my own. And I sought to create a new board to use the cards with. I eventually decided to use an extra Highlands board for the dragon expansion. I did find a very nice homebrew dragon expansion I was almost willing to use its board with my variant using the official cards (or some of them, as some have been removed in my variant, but no new cards have been added). But eventually I decided to just change the text on 3 spaces of the Highlands board, and update my variant rules.
There are a few homebrew characters out there I have been very tempted to print up, but since they are few, and there is no figure, I decided to not do those.
I was very tempted to try a Timescape homebrew for 4th edition but wasn't impressed with what I saw.
So as you can see, I am a bit to picky for 4th edition homebrew, except for alternate endings.
I hope I was able to help by sharing my experience and tastes.