Played my 1st Talisman game with every expansion. The Nether Realm's Pandora's box was stacked randomly with the other alternate endings and played with the Firelands expansion as well. Everything! Even dragons, but using my dragons variant, see here:
It was a very balanced game. And while I say I played with every expansion in this game, I did not play with every card. As noted elsewhere I only play with about half of Blood Moon, no day/nite and most of the heavy Halloween flavored monsters taken out. And a small amount of cards removed from Dragons as well (also as noted).
It was fun everyone loved it.
On the link above, I discuss in a 2nd post (not the initial one) how the variant worked in detail.
Edited by DomaGB, 15 March 2014 - 10:44 AM.